Head-to-head

NVIDIA H100 SXM5 80GB vs AMD Instinct MI300X 192GB

Dedicated comparison page for two real hardware profiles. This is built from your benchmark database, trust metadata, and buyer flow instead of generic spec-sheet comparisons.

Device profile

NVIDIA H100 SXM5 80GB

70B FP16 with substantial context, 405B Q4 with headroom. Production multi-tenant serving at batch 8-64 via TensorRT-LLM or vLLM.

Curated Aggregate·2026-04-0980GB / $25k

Best LLM

612 tok/s

VRAM

80 GB

TDP

700 W

Rating

9.4

Open hardware brief View Amazon

Device profile

AMD Instinct MI300X 192GB

Large-model inference where VRAM capacity matters more than peak compute — 405B Q4 with headroom, 70B FP16 comfortably

Curated Aggregate·2026-03-19192GB / $15k

Best LLM

920 tok/s

VRAM

192 GB

TDP

750 W

Rating

9.3

Open hardware brief Search Amazon

Quick verdict

NVIDIA H100 SXM5 80GB scores 9.4 while AMD Instinct MI300X 192GB scores 9.3 on MyAIHardware's composite rating.

AMD Instinct MI300X 192GB wins VRAM capacity.

NVIDIA H100 SXM5 80GB is the lower-power path.

On shared workload evidence, Llama 3 8B Q4 is benchmarked at 178 tok/s for NVIDIA H100 SXM5 80GB and 122 tok/s for AMD Instinct MI300X 192GB.

Metric	NVIDIA H100 SXM5 80GB	AMD Instinct MI300X 192GB
MyAI rating	9.4	9.3
Best LLM	612 tok/s	920 tok/s
VRAM	80 GB	192 GB
TDP	700 W	750 W
MSRP	$25k	$15k
Workloads	13	12

Shared benchmark rows

Llama 3 8B Q4

-31.5%

NVIDIA H100 SXM5 80GB

178 tok/s

Q4_K_M / 80GB / 2024-11-08

AMD Instinct MI300X 192GB

122 tok/s

Q4_K_M / 192GB / 2025-04-08

Mistral 7B Q4

Mistral 7B

-9.2%

NVIDIA H100 SXM5 80GB

295 tok/s

Q4_K_M / 80GB / 2025-05-08

AMD Instinct MI300X 192GB

268 tok/s

Q4_K_M / 192GB / 2025-05-19

Gemma 2 9B Q4

Gemma 2 9B

-12.6%

NVIDIA H100 SXM5 80GB

215 tok/s

Q4_K_M / 80GB / 2024-10-14

AMD Instinct MI300X 192GB

188 tok/s

Q4_K_M / 192GB / 2025-12-08

DeepSeek-R1 Distill 7B

DeepSeek-R1 7B

-12.2%

NVIDIA H100 SXM5 80GB

245 tok/s

Q4_K_M / 80GB / 2024-08-04

AMD Instinct MI300X 192GB

215 tok/s

Q4_K_M / 192GB / 2026-03-19

Qwen 2.5 14B Q4

Qwen 2.5 14B

-15.5%

NVIDIA H100 SXM5 80GB

168 tok/s

Q4_K_M / 80GB / 2024-10-21

AMD Instinct MI300X 192GB

142 tok/s

Q4_K_M / 192GB / 2024-12-04

Llama 3 70B Q4

+9.1%

NVIDIA H100 SXM5 80GB

66.0 tok/s

Q4_K_M / 80GB / 2024-06-24

AMD Instinct MI300X 192GB

72.0 tok/s

Q4_K_M / 192GB / 2025-07-11

Open radar compare

External quality layer

Best open models likely to fit this class

This shortlist cross-references the external OpenEvals snapshot with an approximate Q4-class VRAM estimate. Use it to sanity-check whether the hardware you are comparing can host strong open models, not just benchmark toy workloads.

Full ingest

microsoft/Phi-3-medium-4k-instruct

14B params · est. 8.4 GB Q4

91.0

NVIDIA H100 SXM5 80GB: likely fitAMD Instinct MI300X 192GB: likely fit

Qwen/Qwen2-72B

73B params · est. 43.6 GB Q4

89.5

NVIDIA H100 SXM5 80GB: likely fitAMD Instinct MI300X 192GB: likely fit

microsoft/Phi-3.5-mini-instruct

3.8B params · est. 2.3 GB Q4

86.2

NVIDIA H100 SXM5 80GB: likely fitAMD Instinct MI300X 192GB: likely fit

internlm/internlm2_5-7b-chat

7.7B params · est. 4.6 GB Q4

86.0

NVIDIA H100 SXM5 80GB: likely fitAMD Instinct MI300X 192GB: likely fit